Open AccessTemporal Patterns and Drug Resistance in CSF Viral Escape Among ART-Experienced HIV-1 Infected Adults
Author(s) -
Shibani S. Mukerji,
Vikas Misra,
David R. Lorenz,
Anna M. CervantesArslanian,
Jennifer Lyons,
Spyridon Chalkias,
Alysse G. Wurcel,
Deirdre Burke,
Nagagopal Venna,
Susan Morgello,
Igor J. Koralnik,
Dana Gabuzda
Publication year - 2017
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000001362
Subject(s) - viremia , cerebrospinal fluid , viral load , resistance mutation , drug resistance , medicine , immunology , human immunodeficiency virus (hiv) , antiretroviral therapy , virology , liter , lentivirus , rna , gastroenterology , viral disease , biology , reverse transcriptase , gene , genetics
Cerebrospinal fluid (CSF) viral escape is an increasingly recognized clinical event among HIV-1-infected adults. We analyzed longitudinal data and drug-resistance mutations to characterize profiles of HIV-1-infected patients on antiretroviral therapy with discordant CSF and plasma HIV-1 RNA levels.