Open AccessBrief Report
Author(s) -
Catherine A. Koss,
Paul Natureeba,
Dorcas Nyafwono,
Albert Plenty,
Julia Mwesigwa,
Bridget Nzarubara,
Tamara D. Clark,
Theodore Ruel,
Jane Achan,
Edwin D. Charlebois,
Deborah Cohan,
Moses R. Kamya,
Diane V. Havlir,
Sera L. Young
Publication year - 2016
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000860
Subject(s) - lopinavir , medicine , odds ratio , breastfeeding , efavirenz , lopinavir/ritonavir , confidence interval , pregnancy , nevirapine , ritonavir , viral load , breast feeding , human immunodeficiency virus (hiv) , antiretroviral therapy , obstetrics , pediatrics , immunology , biology , genetics
Food insecurity is associated with poor virologic outcomes, but this has not been studied during pregnancy and breastfeeding. We assessed sustained viral suppression from 8 weeks on antiretroviral therapy to 48 weeks postpartum among 171 pregnant and breastfeeding Ugandan women; 74.9% experienced food insufficiency. In multivariable analysis, food insufficiency [adjusted odds ratio (aOR) 0.38, 95% confidence interval (CI): 0.16 to 0.91], higher pretreatment HIV-1 RNA (aOR 0.55 per 10-fold increase, 95% CI: 0.37 to 0.82), and lopinavir/ritonavir versus efavirenz (aOR 0.49, 95% CI: 0.24 to 0.96) were associated with lower odds of sustained viral suppression. Interventions to address food security may improve virologic outcomes among HIV-infected women.