Open AccessSoluble CD163 Is Associated With Shortened Telomere Length in HIV-Infected Patients
Author(s) -
Suman Srinivasa,
Kathleen V. Fitch,
Eva Petrow,
Tricia H. Burdo,
Kenneth C. Williams,
Janet Lo,
Hélène Côté,
Steven Grinspoon
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000329
Subject(s) - serostatus , cd163 , human immunodeficiency virus (hiv) , immune system , cohort , medicine , telomere , immunology , multivariate analysis , univariate analysis , gastroenterology , biology , viral load , macrophage , genetics , gene , in vitro
Telomere length (TL) and immune activation markers were measured in a cohort of HIV-infected (n = 102) and age-matched non-HIV-infected (n = 41) men. TL was significantly shorter in HIV-infected compared with non-HIV-infected subjects (P = 0.04). Univariate analysis revealed a strong inverse relationship of TL to sCD163, and thus, monocyte/macrophage activation, among the HIV group (ρ = -0.30, P = 0.003). In multivariate modeling among the whole group, HIV-positive serostatus (P = 0.06) and sCD163 (P = 0.05) remained predictors of TL controlling for age and smoking status. Our data demonstrate that increased immune activation relates to shorter TL in HIV.