Open AccessRational Design and Characterization of the Novel, Broad and Potent Bispecific HIV-1 Neutralizing Antibody iMabm36
Author(s) -
Ming Sun,
Craig Pace,
Xin Yao,
Faye Yu,
Neal N. Padte,
Yaoxing Huang,
Michael S. Seaman,
Qihan Li,
David D. Ho
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000218
Subject(s) - bispecific antibody , human immunodeficiency virus (hiv) , virology , neutralizing antibody , antibody , rational design , medicine , immunology , biology , monoclonal antibody , genetics
Although broadly neutralizing monoclonal antibodies (bNAbs) have always been considered to be a potential therapeutic option for the prophylaxis and treatment of HIV infection, their lack of breadth against all HIV variants has been one of the limiting factors. To provide sufficient neutralization breadth and potency against diverse viruses, including neutralization escape mutants, strategies to combine different bNAbs have been explored recently.