Open AccessTGFβ-Mediated Downregulation of Thrombopoietin Is Associated With Platelet Decline in Asymptomatic SIV Infection
Author(s) -
Kelly A. Metcalf Pate,
Claire E. Lyons,
Jamie L. Dorsey,
Suzanne E. Queen,
Robert J. Adams,
Craig N. Morrell,
Joseph L. Mankowski
Publication year - 2014
Publication title -
journal of acquired immune deficiency syndromes
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.162
H-Index - 157
eISSN - 1944-7884
pISSN - 1525-4135
DOI - 10.1097/qai.0000000000000048
Subject(s) - thrombopoietin , downregulation and upregulation , asymptomatic , platelet , immunology , medicine , virology , biology , haematopoiesis , gene , genetics , stem cell
Thrombocytopenia is a known consequence of HIV infection, and decreased production of platelets has been previously implicated in the pathogenesis of platelet decline during asymptomatic infection. Thrombopoietin (THPO) drives platelet production by stimulating the maturation of bone marrow megakaryocytes and can be transcriptionally downregulated by cytokines that are increased during infection such as transforming growth factor β (TGFβ) and platelet factor 4 (pf4).