Open AccessHIV immune activation drives increased Eomes expression in memory CD8 T cells in association with transcriptional downregulation of CD127
Author(s) -
Rebecca B. Hasley,
Changwan Hong,
Wenqing Li,
Travis J. Friesen,
Yoriko Nakamura,
Grace Y. Kim,
Jung Hyun Park,
Julie A. Hixon,
Scott K. Durum,
Zonghui Hu,
Michael C. Sneller,
Raphael M. Oguariri,
Tomozumi Imamichi,
H. Clifford Lane,
Marta Catálfamo
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283618487
Subject(s) - downregulation and upregulation , interleukin 7 receptor , immune system , human immunodeficiency virus (hiv) , immunology , biology , association (psychology) , cd8 , cytotoxic t cell , microbiology and biotechnology , virology , psychology , t cell , genetics , in vitro , il 2 receptor , gene , psychotherapist
During HIV infection distinct mechanisms drive immune activation of the CD4 and CD8 T cells leading to CD4 T-cell depletion and expansion of the CD8 T-cell pool. This immune activation is polyclonal and extends beyond HIV-specific T cells. One consequence of this immune activation is a profound decrease in IL-7Rα (CD127) expression on memory CD8 T cells. The mechanisms leading to this are unknown and because of the potential impact of reduced IL-7 signaling in memory T cells specific to HIV and other pathogens, in the present study we examined the molecular mechanisms implicated in this downregulation of CD127.