Open AccessVitamin D attenuates nucleoside reverse transcriptase inhibitor induced human skeletal muscle mitochondria DNA depletion
Author(s) -
Grant R. Campbell,
Zachary T. Pallack,
Stephen A. Spector
Publication year - 2013
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32836010dd
Subject(s) - reverse transcriptase , nucleoside reverse transcriptase inhibitor , reverse transcriptase inhibitor , skeletal muscle , nucleoside , mitochondrion , mitochondrial dna , dna , chemistry , biology , endocrinology , biochemistry , rna , gene
To evaluate the impact of the active metabolite of vitamin D, 1α,25-dihydroxycholecalciferol (1,25D3), on nucleoside reverse transcriptase inhibitor (NRTI) induced mitochondrial DNA (mtDNA) depletion in human skeletal muscle myoblasts and myotubes.