Open AccessPolymorphism of gp41 glycoprotein might influence the progression to disease in HIV-1 infection
Author(s) -
Valérie Potard,
Zaïna Ait-Arkoub,
Henri Agut
Publication year - 2013
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835f6b30
Subject(s) - gp41 , glycoprotein , biology , isoleucine , virology , immunology , antibody , immunopathology , human immunodeficiency virus (hiv) , epitope , genetics , leucine , amino acid
We analysed the impact of envelope glycoprotein gp41 polymorphism on the persistence of long-term nonprogressor (LTNP) status in 59 HIV-1-infected individuals over a period of time exceeding 6 years. The presence of a leucine at the codon 830, instead of the predominant isoleucine residue, was significantly associated with nonprogression, independently of the presence of two particular classes of antigp41 antibodies (antigp41 IgG2 and anti-SWSNKS peptide) previously reported as markers of LTNP status.