Open AccessRaltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery
Author(s) -
Marta Massanella,
Eugènia Negredo,
Jordi Puig,
María C. Puertas,
María J. Buzón,
Núria Pérez-Álvarez,
Jorge Carrillo,
Bonaventura Clotet,
Javier MartinezPicado,
Julià Blanco
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328359f20f
Subject(s) - raltegravir , cd38 , cd8 , t cell , cytotoxic t cell , immunology , viral load , hyperactivation , ex vivo , biology , medicine , immune system , in vivo , human immunodeficiency virus (hiv) , in vitro , stem cell , antiretroviral therapy , microbiology and biotechnology , cd34 , biochemistry
Immunodiscordant HIV-infected patients show viral suppression during antiretroviral therapy but fail to recover CD4 T cells. Immunodiscordance is characterized by partial CD4 T-cell immunodeficiency and increased inflammation, activation and immunosenescence in both CD4 and CD8 T cells.