Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery | Zendy

Marta Massanella | Zendy; Eugènia Negredo | Zendy; Jordi Puig | Zendy; María C. Puertas | Zendy; María J. Buzón | Zendy; Núria PérezÁlvarez | Zendy; Jorge Carrillo | Zendy; Bonaventura Clotet | Zendy; Javier MartínezPicado | Zendy; Julià Blanco | Zendy

Open Access

Raltegravir intensification shows differing effects on CD8 and CD4 T cells in HIV-infected HAART-suppressed individuals with poor CD4 T-cell recovery

Author(s) -

Marta Massanella,

Eugènia Negredo,

Jordi Puig,

María C. Puertas,

María J. Buzón,

Núria PérezÁlvarez,

Jorge Carrillo,

Bonaventura Clotet,

Javier MartínezPicado,

Julià Blanco

Publication year - 2012

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e328359f20f

Subject(s) - raltegravir , cd38 , cd8 , t cell , cytotoxic t cell , immunology , viral load , hyperactivation , ex vivo , biology , medicine , immune system , in vivo , human immunodeficiency virus (hiv) , in vitro , stem cell , antiretroviral therapy , microbiology and biotechnology , cd34 , biochemistry

Immunodiscordant HIV-infected patients show viral suppression during antiretroviral therapy but fail to recover CD4 T cells. Immunodiscordance is characterized by partial CD4 T-cell immunodeficiency and increased inflammation, activation and immunosenescence in both CD4 and CD8 T cells.

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