Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients | Zendy

Sophie Bouchat | Zendy; Jean-Stéphane Gatot | Zendy; Kabamba Kabeya | Zendy; Christelle Cardona | Zendy; Laurence Colin | Zendy; Georges Herbein | Zendy; Christoph Stephan | Zendy; Nathan Clumeck | Zendy; O. Lambotte | Zendy; Christine Rouzioux | Zendy; Olivier Rohr | Zendy; Carine Van Lint | Zendy

Open Access

Histone methyltransferase inhibitors induce HIV-1 recovery in resting CD4+ T cells from HIV-1-infected HAART-treated patients

Author(s) -

Sophie Bouchat,

Jean-Stéphane Gatot,

Kabamba Kabeya,

Christelle Cardona,

Laurence Colin,

Georges Herbein,

Christoph Stephan,

Nathan Clumeck,

O. Lambotte,

Christine Rouzioux,

Olivier Rohr,

Carine Van Lint

Publication year - 2012

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32835535f5

Subject(s) - peripheral blood mononuclear cell , ex vivo , cd8 , methyltransferase , in vivo , vorinostat , biology , histone deacetylase inhibitor , cancer research , histone methyltransferase , immunology , virology , histone deacetylase , epigenetics , histone , immune system , in vitro , methylation , biochemistry , microbiology and biotechnology , gene

Reactivation of HIV-1 expression in persistent reservoirs together with an efficient HAART has been proposed as an adjuvant therapy aimed at reaching a functional cure for HIV. Previously, H3K9 methylation was shown to play a major role in chromatin-mediated repression of the HIV-1 promoter. Here, we evaluated the therapeutic potential of histone methyltransferase inhibitors (HMTIs) in reactivating HIV-1 from latency.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research