Open AccessThe design and evaluation of HIV-1 vaccines
Author(s) -
Kevin O. Saunders,
Rebecca S. Rudicell,
Gary J. Nabel
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32835474d2
Subject(s) - hiv vaccine , optimism , immunization , human immunodeficiency virus (hiv) , virology , immunology , medicine , aids vaccines , clinical trial , vaccination , immune system , vaccine trial , psychology , social psychology , pathology
There is renewed optimism that the goal of developing a highly effective AIDS vaccine is attainable. The HIV-1 vaccine field has seen its first trial of a vaccine candidate that prevents infection. Although modest in efficacy, this finding, along with the recent discovery that the human immune system can produce broadly neutralizing antibodies capable of inhibiting greater than 90% of circulating viruses, provides a guide for the rational design of vaccines and protection by passive immunization. Together, these findings will help shape the next generation of HIV vaccines.