Open AccessGenetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART
Author(s) -
Aline Gasparotto,
Eduardo Sprinz,
Rosmeri Kuhmmer Lazzaretti,
Regina Kuhmmer,
Jussara María Silveira,
Rossana Patrícia Basso,
Cézar Arthur Tavares Pinheiro,
Mariângela F. Silveira,
Jorge Pinto Ribeiro,
Vanessa Suñé Mattevi
Publication year - 2012
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32834db3ac
Subject(s) - lipodystrophy , anthropometry , metabolic syndrome , medicine , single nucleotide polymorphism , dyslipidemia , lipoatrophy , biology , endocrinology , estrogen receptor , estrogen receptor alpha , sexual dimorphism , physiology , obesity , genotype , genetics , immunology , viral load , human immunodeficiency virus (hiv) , gene , cancer , breast cancer , antiretroviral therapy
To investigate genetic single nucleotide polymorphisms (SNPs) in estrogen receptor-α (ERα) (ESR1, rs2234693, rs1801132, rs7757956 and rs2813544) and ERβ (ESR2, rs3020450, rs7154455 and rs4986938) genes and relate them to the adverse effects lipodystrophy, dyslipidemia and metabolic syndrome as well as to differences in their prevalence between sexes in HIV-infected individuals on HAART.