Open AccessIL28B gene polymorphisms and viral kinetics in HIV/hepatitis C virus-coinfected patients treated with pegylated interferon and ribavirin
Author(s) -
Norma Rallón,
Vincent Soriano,
Susanggie,
Clara Restrepo,
David B. Goldstein,
Eugenia Vispo,
John G. McHutchison,
José M. Benito
Publication year - 2011
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283471cae
Subject(s) - ribavirin , hepatitis c virus , interleukin 28b , pegylated interferon , hepatitis c , medicine , viral load , genotype , population , virology , single nucleotide polymorphism , gastroenterology , immunology , biology , virus , gene , biochemistry , environmental health
A single nucleotide polymorphism (SNP) upstream of the IL28B gene (rs12979860) predicts sustained virological response (SVR) to peginterferon-ribavirin therapy in chronic hepatitis C patients. There is scarce information regarding the influence of this IL28B SNP on early viral kinetics during therapy, particularly in patients coinfected with HIV, in whom treatment response is lower than in hepatitis C virus (HCV)-monoinfected patients.