HIV-1 decreases the levels of neurotrophins in human lymphocytes | Zendy

Valeriya Avdoshina | Zendy; Alfredo GarzinoDemo | Zendy; Alessia Bachis | Zendy; Maria CG Monaco | Zendy; Pauline M. Maki | Zendy; Rochelle E. Tractenberg | Zendy; Chenglong Liu | Zendy; Mary Young | Zendy; Italo Mocchetti | Zendy

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HIV-1 decreases the levels of neurotrophins in human lymphocytes

Author(s) -

Valeriya Avdoshina,

Alfredo GarzinoDemo,

Alessia Bachis,

Maria CG Monaco,

Pauline M. Maki,

Rochelle E. Tractenberg,

Chenglong Liu,

Mary Young,

Italo Mocchetti

Publication year - 2011

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32834671b3

Subject(s) - neurotrophin , neurotrophic factors , brain derived neurotrophic factor , neurotrophin 3 , human immunodeficiency virus (hiv) , immunology , apoptosis , nerve growth factor , medicine , immunopathology , biology , psychology , receptor , genetics

Neurotrophins control cell survival. Therefore, we examined whether HIV-1 reduces neurotrophin levels. Serum of HIV-positive individuals exhibited lower concentrations of brain-derived neurotrophic factor (BDNF), but not of other neurotrophins, than HIV-negative individuals. In addition, R5 and X4 strains of HIV-1 decreased BDNF expression in T cells. Our results support the hypothesis that reduced levels of BDNF may be a risk factor for T-cell apoptosis and for neurological complications associated with HIV-1 infection.

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