Open AccessSigmoid Th17 populations, the HIV latent reservoir, and microbial translocation in men on long-term antiretroviral therapy
Author(s) -
Duncan Chege,
Prameet M. Sheth,
Taylor Kain,
Connie J. Kim,
Colin Kovacs,
Mona Loutfy,
Roberta Halpenny,
Gabor Kandel,
TaeWook Chun,
Mario Ostrowski,
Rupert Kaul
Publication year - 2011
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328344cefb
Subject(s) - viremia , immunology , chromosomal translocation , immune system , biology , systemic inflammation , inflammation , human immunodeficiency virus (hiv) , gene , genetics
Th17 cells play an important role in mucosal defence and repair and are highly susceptible to infection by HIV. Antiretroviral therapy (ART) suppresses HIV viremia and can restore CD4(+) numbers in the blood and gastrointestinal mucosa, but the resolution of systemic inflammation and gut microbial translocation is often incomplete. We hypothesized that this might relate to persistent dysregulation of gut CD4(+) Th17 subsets.