Open AccessAssociation between HLA inheritance and asthma medication use in HIV positive children
Author(s) -
Samuel B. Foster,
Ming Lü,
Bruce Thompson,
Kenneth C. Rich,
Larissa Matukas,
Rosemarie D. Mason,
Robert Winchester,
Kelly S. MacDonald,
William T. Shearer
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32833cba08
Subject(s) - asthma , medicine , human leukocyte antigen , immunology , asthma medication , allele , sida , human immunodeficiency virus (hiv) , pediatrics , viral disease , antigen , biology , genetics , gene
This study's purpose was to determine whether asthma medication use in HIV positive children is associated with human leukocyte antigen (HLA) alleles. We reviewed HLA and medication data collected during the Women and Infants Transmission Study for 124 HIV positive children and their mothers. Analysis revealed that HLA-A68 (P = 0.006) was independent and predictive for time to first asthma medication use. There was a preventive association of Cw6 (P = 0.008) with asthma time. Highly active antiretroviral therapy (HAART) was also associated with time to first asthma medication use (P = 0.05). HLA alleles may modulate risk of developing a need for asthma medications and seem to function independently of the actions of HAART therapy.