Open AccessOral uridine supplementation antagonizes the peripheral neuropathy and encephalopathy induced by antiretroviral nucleoside analogues
Author(s) -
Nils Venhoff,
Dirk Lebrecht,
Catherine Deveaud,
Bertrand Beauvoit,
Jacques Bonnet,
Klaus Müller,
Janbernd Kirschner,
Ana C Venhoff,
Ulrich A. Walker
Publication year - 2010
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328335cdea
Subject(s) - uridine , nucleoside , peripheral neuropathy , encephalopathy , medicine , nucleoside analogue , virology , pharmacology , chemistry , endocrinology , rna , biochemistry , diabetes mellitus , gene
Peripheral neuropathy and central nervous system neurodegeneration may result from the mitochondrial toxicity of some antiretroviral nucleoside analogues. We investigated whether this neuropathology may be antagonized by uridine supplementation in vivo.