Open AccessExpression of latent human immunodeficiency type 1 is induced by novel and selective histone deacetylase inhibitors
Author(s) -
Nancie M. Archin,
Kara S. Keedy,
Amy S. Espeseth,
Herbert Dang,
Daria J. Hazuda,
David M. Margolis
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32832ec1dc
Subject(s) - histone deacetylase , histone , acetylation , biology , chromatin , psychological repression , trichostatin a , long terminal repeat , cancer research , gene expression , gene , genetics
A family of histone deacetylases (HDACs) mediates chromatin remodeling, and repression of gene expression. Deacetylation of histones within the HIV-1 long terminal repeat (LTR) by HDACs plays a key role in the maintenance of latency, whereas acetylation of histones about the LTR is linked to proviral expression and escape of HIV from latency. Global HDAC inhibition may adversely affect host gene expression, leading to cellular toxicities. Potent inhibitors selective for HDACs that maintain LTR repression could be ideal antilatency therapeutics.