Open AccessExcision of nucleoside analogs in mitochondria by p53 protein
Author(s) -
Mary Bakhanashvili,
Shai Grinberg,
Elad Bonda,
Galia Rahav
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e328329c74e
Subject(s) - biology , dna polymerase , mitochondrial dna , microbiology and biotechnology , polymerase , exonuclease , mitochondrion , primer (cosmetics) , dna , nucleoside , dna damage , dna polymerase i , dna polymerase ii , biochemistry , chemistry , reverse transcriptase , rna , gene , organic chemistry
Nucleoside analogs, used against HIV, can be incorporated into a mitochondrial DNA by DNA polymerase gamma. Both the decrease in mitochondrial DNA and increased mutations of mitochondrial DNA may lead to mitochondrial diseases. The tumor suppressor protein p53 exhibits 3' --> 5' exonuclease activity and can provide a proofreading function for DNA polymerases. In the present study, we investigated the ability of p53 to excise incorporated nucleoside analogs from DNA in mitochondria.