Open AccessLeprosy reaction as a manifestation of immune reconstitution inflammatory syndrome: a case series of a Brazilian cohort
Author(s) -
Vinicius Martins de Menezes,
Anna Maria Sales,
Ximena Illarramendi,
Alice Miranda,
Mariza G. Morgado,
Maria Clara Gutierrez-Galhardo,
Euzenir Nunes Sarno,
José Augusto da Costa Nery
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283291405
Subject(s) - leprosy , immune reconstitution inflammatory syndrome , immune system , cohort , immunology , medicine , immune reaction , disease , immunopathology , human immunodeficiency virus (hiv) , dermatology , viral load , antiretroviral therapy
Several case reports have demonstrated that the immune reconstitution inflammatory syndrome induces reversal reaction in HIV and leprosy-coinfected patients. The present study describes 10 cases of immune reconstitution inflammatory-associated reversal reaction. The patients evolved satisfactorily despite presenting a more severe form of the disease and the fact that three required an additional use of corticoids. The present study, the largest case series published to date, demonstrates that leprosy reaction is a manifestation of immune reconstitution.