Open AccessFailure of immunologic criteria to appropriately identify antiretroviral treatment failure in Uganda
Author(s) -
Steven J. Reynolds,
Gertrude Nakigozi,
Kevin Newell,
Anthony Ndyanabo,
Ronald Galiwongo,
Iga Boaz,
Thomas C. Quinn,
Ron Gray,
Maria J. Wawer,
David Serwadda
Publication year - 2009
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3283262a78
Subject(s) - viral load , medicine , regimen , cohort , clinical endpoint , antiretroviral treatment , observational study , cohort study , gold standard (test) , antiretroviral therapy , human immunodeficiency virus (hiv) , clinical trial , immunology
Most antiretroviral treatment program in resource-limited settings use immunologic or clinical monitoring to measure response to therapy and to decide when to change to a second-line regimen. Our objective was to evaluate immunologic failure criteria against gold standard virologic monitoring.