Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection | Zendy

Lishomwa C. Ndhlovu | Zendy; Joan M. Chapman | Zendy; Aashish R. Jha | Zendy; Jennifer SnyderCappione | Zendy; Moraima Pagán | Zendy; Fábio E. Leal | Zendy; Brigid S. Boland | Zendy; Philip J. Norris | Zendy; Michael Rosenberg | Zendy; Douglas F. Nixon | Zendy

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Suppression of HIV-1 plasma viral load below detection preserves IL-17 producing T cells in HIV-1 infection

Author(s) -

Lishomwa C. Ndhlovu,

Joan M. Chapman,

Aashish R. Jha,

Jennifer SnyderCappione,

Moraima Pagán,

Fábio E. Leal,

Brigid S. Boland,

Philip J. Norris,

Michael Rosenberg,

Douglas F. Nixon

Publication year - 2008

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e3282ff884e

Subject(s) - viremia , viral load , immunology , virology , proinflammatory cytokine , cytokine , human immunodeficiency virus (hiv) , secretion , biology , t cell , immune system , inflammation , biochemistry

IL-17 is proinflammatory cytokine secreted by a unique CD4+ T (Th17) cell subset and proposed to play a role in host defense. We hypothesized that Th17 cells are lost in HIV-1 infection. HIV-1-infected children with plasma viremia below 50 copies/ml had IL-17 production, whereas those with detectable viremia had minimal secretion. These results imply viral-mediated destruction or impairment of Th17 cells and argue for complete suppression of viremia for reconstitution of Th17 cells.

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