Open AccessSingle-nucleotide polymorphisms in human β-defensin-1 gene in Mozambican HIV-1-infected women and correlation with virologic parameters
Author(s) -
Silvia Baroncelli,
Elisabetta Ricci,
Mauro Andreotti,
Giovanni Guidotti,
Paola Germano,
Maria Cristina Marazzi,
Stefano Vella,
Leonardo Palombi,
Anita De Rossi,
Marina Giuliano
Publication year - 2008
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3282fd6e0c
Subject(s) - genotype , defensin , single nucleotide polymorphism , biology , lentivirus , virology , beta defensin , gene , immunology , untranslated region , breast milk , human immunodeficiency virus (hiv) , viral disease , genetics , rna , biochemistry
We analyzed single nucleotide polymorphisms in the 5'-untranslated region (-44C/G and -52G/A) of the beta-defensin-1 gene in 78 Mozambican HIV-1-infected mothers. We observed significantly lower levels of HIV-1 RNA in breast milk, but not in plasma, in women with the -52GG genotype versus women with the -52GA and -52AA genotypes, supporting the hypothesis that different expression of beta-defensins could have an impact on viral replication in breast milk.