IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages | Zendy

Tomozumi Imamichi | Zendy; Jun Yang | Zendy; Da-Wei Huang | Zendy; Terrence W. Brann | Zendy; Brandie Fullmer | Zendy; Joseph W. Adelsberger | Zendy; Richard A. Lempicki | Zendy; Michael Baseler | Zendy; H. Clifford Lane | Zendy

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IL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages

Author(s) -

Tomozumi Imamichi,

Jun Yang,

Da-Wei Huang,

Terrence W. Brann,

Brandie Fullmer,

Joseph W. Adelsberger,

Richard A. Lempicki,

Michael Baseler,

H. Clifford Lane

Publication year - 2008

Publication title -

aids

Language(s) - Uncategorized

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e3282f3356c

Subject(s) - microbiology and biotechnology , biology , interferon , cytokine , peripheral blood mononuclear cell , gene expression , monocyte , gene , chemistry , virology , immunology , in vitro , biochemistry

IL-27 is a novel anti-HIV cytokine that inhibits HIV-1 replication in both CD4 T cells and monocyte-derived macrophages (MDM) as IFN-alpha does. To elucidate the mechanism of the antiviral activity, we compared the activity and the gene expression profile of IL-27-treated cells with that of IFN-alpha-treated cells.

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