Open AccessIL-27, a novel anti-HIV cytokine, activates multiple interferon-inducible genes in macrophages
Author(s) -
Tomozumi Imamichi,
Jun Yang,
Dawei Huang,
Terrence W. Brann,
Brandie Fullmer,
Joseph W. Adelsberger,
Richard A. Lempicki,
Michael Baseler,
H. Clifford Lane
Publication year - 2008
Publication title -
aids
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3282f3356c
Subject(s) - microbiology and biotechnology , biology , interferon , cytokine , peripheral blood mononuclear cell , monocyte , gene expression , gene , chemistry , virology , immunology , in vitro , biochemistry
IL-27 is a novel anti-HIV cytokine that inhibits HIV-1 replication in both CD4 T cells and monocyte-derived macrophages (MDM) as IFN-alpha does. To elucidate the mechanism of the antiviral activity, we compared the activity and the gene expression profile of IL-27-treated cells with that of IFN-alpha-treated cells.