Open AccessEfficacy of a multigenic protein vaccine containing multimeric HIV gp160 against heterologous SHIV clade C challenges
Author(s) -
Robert A. Rasmussen,
Helena Ong,
Ruijiang Song,
Agnès Laurence Chenine,
Mila Ayash-Rashkovsky,
Shiu Lok Hu,
Patricia Polacino,
James G. Else,
Francis J. Novembre,
Ruth M. Ruprecht
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32828684ea
Subject(s) - immunogen , heterologous , virology , biology , vaccination , aids vaccines , hiv vaccine , antibody , neutralizing antibody , immune system , immunogenicity , virus , lentivirus , viral load , gene , immunology , vaccine trial , viral disease , genetics , monoclonal antibody
To determine whether multigenic protein immunogens including native, trimeric HIV clade C (HIV-C) gp160 could cross-protect macaques against mucosal challenge with clade C (SHIV-C) mismatched for env.