Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir | Zendy

Nicola Gianotti | Zendy; Monica Guffanti | Zendy; Laura Galli | Zendy; Alberto Margonato | Zendy; Giulia Chiaravalli | Zendy; Alba Bigoloni | Zendy; Adriano Lazzarin | Zendy; Antonella Castagna | Zendy

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Electrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir

Author(s) -

Nicola Gianotti,

Monica Guffanti,

Laura Galli,

Alberto Margonato,

Giulia Chiaravalli,

Alba Bigoloni,

Adriano Lazzarin,

Antonella Castagna

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32826fbc6a

Subject(s) - atazanavir , medicine , interquartile range , qrs complex , atenolol , asymptomatic , qt interval , pr interval , cardiology , bundle branch block , human immunodeficiency virus (hiv) , atrioventricular block , right bundle branch block , abacavir , electrocardiography , gastroenterology , viral load , antiretroviral therapy , virology , heart rate , blood pressure

The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P < 0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.

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