Open AccessElectrocardiographic changes in HIV-infected, drug-experienced patients being treated with atazanavir
Author(s) -
Nicola Gianotti,
Monica Guffanti,
Laura Galli,
Alberto Margonato,
Giulia Chiaravalli,
Alba Bigoloni,
Adriano Lazzarin,
Antonella Castagna
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32826fbc6a
Subject(s) - atazanavir , medicine , interquartile range , qrs complex , atenolol , asymptomatic , qt interval , pr interval , cardiology , bundle branch block , human immunodeficiency virus (hiv) , atrioventricular block , right bundle branch block , abacavir , electrocardiography , gastroenterology , viral load , antiretroviral therapy , virology , heart rate , blood pressure
The QRS interval of 56 out of 75 (74.7%) HIV-infected, drug-experienced patients (66.7% men) increased during treatment with boosted or unboosted atazanavir by a median 5 ms (interquartile range 0-9; P < 0.0001); the PR and the QTc intervals did not change significantly. New asymptomatic bundle branch blocks were observed in four patients; one subject with a baseline first-degree atrioventricular block developed symptomatic bradyarrhythmia while receiving atenolol. The electrocardiographic monitoring of patients treated with atazanavir seems advisable.