Open AccessEnhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART
Author(s) -
Per Björkman,
Leo Flamholc,
Vilma Molnegren,
A. Marshall,
Nuray Güner,
Anders Widell
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32823bc9b7
Subject(s) - gb virus c , virology , virus , viral replication , viral disease , lentivirus , rna , sida , human immunodeficiency virus (hiv) , replication (statistics) , medicine , viral load , flaviviridae , biology , immunology , gene , genetics
In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.