Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART | Zendy

Per Björkman | Zendy; Leo Flamholc | Zendy; Vilma Molnegren | Zendy; Aline Marshall | Zendy; Nuray Güner | Zendy; Anders Widell | Zendy

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Enhanced and resumed GB virus C replication in HIV-1-infected individuals receiving HAART

Author(s) -

Per Björkman,

Leo Flamholc,

Vilma Molnegren,

Aline Marshall,

Nuray Güner,

Anders Widell

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32823bc9b7

Subject(s) - gb virus c , virology , virus , viral replication , viral disease , lentivirus , rna , sida , human immunodeficiency virus (hiv) , replication (statistics) , medicine , viral load , flaviviridae , biology , immunology , gene , genetics

In patients co-infected with HIV-1 and GB virus C (GBV-C), the disappearance of GBV-C RNA has been associated with accelerated disease progression. We studied longitudinal GBV-C viral titres in 28 HIV-1/GVB-C co-infected individuals receiving HAART. During HAART, median GBV-C RNA titres increased from 95 to 6000 copies/ml (P < 0.001). In patients interrupting HAART, GBV-C-RNA titres decreased as HIV replication resumed. These findings further support the theory that GBV-C replication could depend on the dynamics of HIV progression.

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