Open AccessCCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1
Author(s) -
Alonso Heredia,
Bruce L. Gilliam,
Anthony L. DeVico,
Nhut Le,
Douty Bamba,
Robin Flinko,
George K. Lewis,
Robert C. Gallo,
Robert Redfield
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32815278ea
Subject(s) - enfuvirtide , infectivity , viral replication , virology , biology , virus , cell culture , lentivirus , microbiology and biotechnology , immunology , viral disease , genetics , gp41 , antibody , epitope
Studies in cell lines have demonstrated that CCR5 coreceptor levels influence the replication efficiency and Enfuvirtide (T-20) susceptibility of R5 HIV-1 strains. At present, however, the role that CCR5 levels on primary CD4 T cells--which are markedly lower than in cell lines and vary only approximately fivefold among most donors--may play in virus replication levels or susceptibility to T-20 is not known. In the present study we evaluated the impact of differences in CCR5 levels among donor CD4 T cells on the infection efficiency and T-20 susceptibility of R5 HIV-1.