CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1 | Zendy

Alonso Heredia | Zendy; Bruce L. Gilliam | Zendy; Anthony L. DeVico | Zendy; Nhut Le | Zendy; Douty Bamba | Zendy; Robin Flinko | Zendy; George K. Lewis | Zendy; Robert C. Gallo | Zendy; Robert Redfield | Zendy

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CCR5 density levels on primary CD4 T cells impact the replication and Enfuvirtide susceptibility of R5 HIV-1

Author(s) -

Alonso Heredia,

Bruce L. Gilliam,

Anthony L. DeVico,

Nhut Le,

Douty Bamba,

Robin Flinko,

George K. Lewis,

Robert C. Gallo,

Robert Redfield

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32815278ea

Subject(s) - enfuvirtide , infectivity , viral replication , virology , biology , virus , cell culture , lentivirus , microbiology and biotechnology , immunology , viral disease , genetics , gp41 , antibody , epitope

Studies in cell lines have demonstrated that CCR5 coreceptor levels influence the replication efficiency and Enfuvirtide (T-20) susceptibility of R5 HIV-1 strains. At present, however, the role that CCR5 levels on primary CD4 T cells--which are markedly lower than in cell lines and vary only approximately fivefold among most donors--may play in virus replication levels or susceptibility to T-20 is not known. In the present study we evaluated the impact of differences in CCR5 levels among donor CD4 T cells on the infection efficiency and T-20 susceptibility of R5 HIV-1.

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