Open AccessThe toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania
Author(s) -
Bart Ferwerda,
Gibson Kibiki,
Mihai G. Netea,
W.M.V. Dolmans,
André J. van der Ven
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32814e6b2d
Subject(s) - tuberculosis , tlr4 , immunology , mycobacterium tuberculosis , tanzania , toll like receptor , cohort , receptor , lentivirus , virology , biology , medicine , human immunodeficiency virus (hiv) , viral disease , immune system , pathology , innate immune system , environmental science , environmental planning
Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.