The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania | Zendy

Bart Ferwerda | Zendy; Gibson Kibiki | Zendy; Mihai G. Netea | Zendy; W.M.V. Dolmans | Zendy; André van der Ven | Zendy

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The toll-like receptor 4 Asp299Gly variant and tuberculosis susceptibility in HIV-infected patients in Tanzania

Author(s) -

Bart Ferwerda,

Gibson Kibiki,

Mihai G. Netea,

W.M.V. Dolmans,

André van der Ven

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32814e6b2d

Subject(s) - tuberculosis , tlr4 , immunology , mycobacterium tuberculosis , tanzania , toll like receptor , cohort , receptor , lentivirus , virology , biology , medicine , human immunodeficiency virus (hiv) , viral disease , immune system , pathology , innate immune system , environmental science , environmental planning

Toll-like receptor 4 (TLR4) plays an important role in the pattern recognition of Mycobacterium tuberculosis, and polymorphisms in the TLR4 gene influence the function of the receptor. We therefore investigated in a cohort of HIV-infected Tanzanian patients whether the Asp299Gly TLR4 polymorphism is associated with the development of active tuberculosis. We found a greater risk of developing active tuberculosis as well as a reduction in CD4 T-cell counts in patients with the Asp299Gly TLR4 polymorphism.

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