Open AccessWHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda
Author(s) -
Joseph Kagaayi,
Fredrick Makumbi,
Gertrude Nakigozi,
Maria J. Wawer,
Ronald H. Gray,
David Serwadda,
Steven J. Reynolds
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32810c8dce
Subject(s) - antiretroviral therapy , predictive value , medicine , human immunodeficiency virus (hiv) , sida , oncology , immunology , viral disease , viral load
The ability of WHO clinical staging to predict CD4 cell counts of 200 cells/microl or less was evaluated among 1221 patients screened for antiretroviral therapy (ART). Sensitivity was 51% and specificity was 88%. The positive predictive value was 64% and the negative predictive value was 81%. Clinical criteria missed half the patients with CD4 cell counts of 200 cells/microl or less, highlighting the importance of CD4 cell measurements for the scale-up of ART provision in resource-limited settings.