WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda | Zendy

Joseph Kagaayi | Zendy; Fredrick Makumbi | Zendy; Gertrude Nakigozi | Zendy; Maria J. Wawer | Zendy; Ronald H. Gray | Zendy; David Serwadda | Zendy; Steven J. Reynolds | Zendy

Open Access

WHO HIV clinical staging or CD4 cell counts for antiretroviral therapy eligibility assessment? An evaluation in rural Rakai district, Uganda

Author(s) -

Joseph Kagaayi,

Fredrick Makumbi,

Gertrude Nakigozi,

Maria J. Wawer,

Ronald H. Gray,

David Serwadda,

Steven J. Reynolds

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e32810c8dce

Subject(s) - antiretroviral therapy , predictive value , medicine , human immunodeficiency virus (hiv) , sida , oncology , immunology , viral disease , viral load

The ability of WHO clinical staging to predict CD4 cell counts of 200 cells/microl or less was evaluated among 1221 patients screened for antiretroviral therapy (ART). Sensitivity was 51% and specificity was 88%. The positive predictive value was 64% and the negative predictive value was 81%. Clinical criteria missed half the patients with CD4 cell counts of 200 cells/microl or less, highlighting the importance of CD4 cell measurements for the scale-up of ART provision in resource-limited settings.

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