Open AccessThe GBV-C envelope glycoprotein E2 does not interact specifically with CD81
Author(s) -
Thomas M. Kaufman,
James H. McLinden,
Jinhua Xiang,
Alfred M. Engel,
Jack T. Stapleton
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3280f77412
Subject(s) - cd81 , glycoprotein , in vitro , virology , receptor , biology , microbiology and biotechnology , viral envelope , virus , chemistry , biochemistry , hepatitis c virus
The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.