The GBV-C envelope glycoprotein E2 does not interact specifically with CD81 | Zendy

Thomas M. Kaufman | Zendy; James H. McLinden | Zendy; Jinhua Xiang | Zendy; Alfred M. Engel | Zendy; Jack T. Stapleton | Zendy

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The GBV-C envelope glycoprotein E2 does not interact specifically with CD81

Author(s) -

Thomas M. Kaufman,

James H. McLinden,

Jinhua Xiang,

Alfred M. Engel,

Jack T. Stapleton

Publication year - 2007

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e3280f77412

Subject(s) - cd81 , glycoprotein , in vitro , virology , receptor , biology , microbiology and biotechnology , viral envelope , virus , chemistry , biochemistry , hepatitis c virus

The addition of GB virus C (GBV-C) E2 protein to cells inhibits HIV replication in vitro, presumably triggered by interactions with a specific cellular receptor. Indirect evidence suggests that CD81 is the GBV-C E2 cellular receptor. We found that E2 binding to cells was not dependent upon human CD81, and that soluble CD81 did not compete with GBV-C E2 for cell binding. GBV-C E2 protein thus does not appear to interact with CD81.

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