Open AccessMitochondrial DNA depletion in HIV-infected patients with chronic hepatitis C and effect of pegylated interferon plus ribavirin therapy
Author(s) -
Carmen de Mendoza,
Luz MartínCarbonero,
Pablo Barreiro,
Michel de Baar,
Natalia Zahonero,
Sonia Rodrı́guez-Nóvoa,
José M. Benito,
Juan González-Lahoz,
Vincent Soriano
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e32805e8742
Subject(s) - ribavirin , pegylated interferon , virology , hepatitis c virus , mitochondrial dna , medicine , peripheral blood mononuclear cell , hepatitis c , viral load , immunology , genotype , hepacivirus , interferon , virus , biology , gene , biochemistry , in vitro
The metabolic stress derived from high levels of virus replication in both HIV and hepatitis C virus (HCV) infections results in mitochondrial DNA depletion, which seems to be enhanced in co-infected patients. The use of nucleoside analogues to treat HIV infection may further increase mtDNA depletion by inhibiting gamma DNA polymerase. Information on the impact of therapy with pegylated interferon (pegIFN) plus ribavirin on mtDNA is scarce and conflicting results have been reported.