Open AccessRapid selection of drug-resistant HIV-1 during the first months of suppressive ART in treatment-naive patients
Author(s) -
Karin J. Metzner,
Kristina Allers,
Pia Rauch,
Thomas Harrer
Publication year - 2007
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0b013e3280121ac6
Subject(s) - viral quasispecies , drug resistance , viral load , resistance mutation , hiv drug resistance , virology , drug , population , reverse transcriptase , integrase inhibitor , medicine , immunology , biology , virus , antiretroviral therapy , pharmacology , microbiology and biotechnology , polymerase chain reaction , genetics , hepatitis c virus , environmental health , gene
Efficient antiretroviral therapy (ART) of HIV-1 infection reduces the viral load to undetectable levels and restores the immune system. However, therapy failure appears in a substantial fraction of patients and is mostly associated with the appearance of drug-resistant viruses. It is still not clear when the drug pressure leads to the earliest selection and appearance of drug-resistant HIV-1 populations. In this study, we wanted to determine whether drug-resistant viruses are already selected during viral decline within the first months of ART.