Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS | Zendy

Elwyn Gabutero | Zendy; Corey Moore | Zendy; S. Mallal | Zendy; Graeme J. Stewart | Zendy; Peter Williamson | Zendy

Open Access

Interaction between allelic variation in IL12B and CCR5 affects the development of AIDS: IL12B/CCR5 interaction and HIV/AIDS

Author(s) -

Elwyn Gabutero,

Corey Moore,

S. Mallal,

Graeme J. Stewart,

Peter Williamson

Publication year - 2006

Publication title -

aids

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.195

H-Index - 216

eISSN - 1473-5571

pISSN - 0269-9370

DOI - 10.1097/qad.0b013e3280117f49

Subject(s) - odds ratio , immunology , allele , medicine , genotype , confidence interval , immune system , biology , genetics , gene

IL-12 is involved in immune surveillance and response that links the innate and adaptive arms of the immune system. Among its many effects, IL-12 increases the cell surface expression of the CCR5 co-receptor for R5 strains of HIV-1, which are predominantly involved in HIV-1 transmission and spread. In the present study we investigated the effect of epistasis between allelic variants of CCR5 and IL12B on the susceptibility to HIV-1 infection and HIV-1 disease progression.

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