Open AccessRenal mitochondrial toxicity: effects of thymidine analogues and tenofovir disoproxil fumarate in African people with HIV
Author(s) -
Matthew Hunt,
Richard Odame Phillips,
Yasmine Hardy,
Dorcas Owusu,
Rosa Mitchelmore,
Mehrab Durrani,
Brendan Payne,
David Chadwick
Publication year - 2022
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000003209
Subject(s) - tenofovir , mitochondrial toxicity , thymidine , toxicity , mitochondrial dna , mitochondrion , medicine , pharmacology , kidney , human immunodeficiency virus (hiv) , virology , biology , dna , biochemistry , gene
We investigated the contributions of thymidine analogue and tenofovir disoproxil fumarate (TDF) antiretroviral therapy on renal mitochondrial toxicity in Ghanaian people with HIV (PWH). Similar levels of renal biochemical and mitochondrial dysfunction were seen, and there was no increased risk in PWH who had sequenced from thymidine analogue to TDF. However, mild renal impairment was associated with mitochondrial DNA damage in TDF but not thymidine analogue-treated PWH. These data support the continued use of TDF in resource-limited settings.