Open AccessThe barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission
Author(s) -
Baxolele Mhlekude,
Annasara Lenman,
Phikolomzi Sidoyi,
Jim Joseph,
Jochen Kruppa,
Charles Bitamazire Businge,
Mana Lungisa Mdaka,
Frank Konietschke,
Andreas Pich,
Gisa Gerold,
Christine Goffinet,
Anwar Suleman Mall
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000003003
Subject(s) - mucus , flow cytometry , lentivirus , context (archaeology) , biology , virus , protease , cell culture , cell , virology , viability assay , microbiology and biotechnology , immunology , viral disease , biochemistry , enzyme , ecology , paleontology , genetics
The cervical mucus plugs are enriched with proteins of known immunological functions. We aimed to characterize the anti-HIV-1 activity of the cervical mucus plugs against a panel of different HIV-1 strains in the contexts of cell-free and cell-associated virus.