Open AccessHIV-1 viral blips are associated with repeated and increasingly high levels of cell-associated HIV-1 RNA transcriptional activity
Author(s) -
Kazuo Suzuki,
Angelique Levert-Mig,
Julie Yeung,
Mitchell Starr,
Jane Cameron,
Raffaella Williams,
Nikolas Rismanto,
Tayla Stark,
Dylan Druery,
Salzeena Prasad,
Cristina Ferrarini,
Imelda Hanafi,
Leon McNally,
Philip Cunningham,
Zhixin Liu,
Takeshi Ishida,
Chin-Shiou Huang,
Velma Oswald,
Louise Evans,
Geoffrey Symonds,
Bruce J. Brew,
John Zaunders
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000003001
Subject(s) - biology , peripheral blood mononuclear cell , rna , virology , viral replication , virus , transcription (linguistics) , microbiology and biotechnology , in vitro , gene , biochemistry , linguistics , philosophy
Some HIV+ patients, virally suppressed on ART, show occasional 'blips' of detectable HIV-1 plasma RNA. We used a new highly sensitive assay of cell-associated HIV-1 RNA to measure transcriptional activity in PBMCs and production of infectious virus from the viral reservoir, in patients with and without 'blips'.