Open AccessAssociations between efavirenz concentrations, pharmacogenetics and neurocognitive performance in people living with HIV in Nigeria
Author(s) -
Jacinta N. Nwogu,
Monica Gandhi,
Andrew Owen,
Saye Khoo,
Babafemi Taiwo,
Adeniyi Olagunju,
Baiba Berzins,
Hideaki Okochi,
Regina Tallerico,
Kevin Robertson,
Chinedum P. Babalola
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002984
Subject(s) - efavirenz , neurocognitive , pharmacokinetics , interquartile range , cyp2b6 , medicine , abacavir , pharmacology , human immunodeficiency virus (hiv) , viral load , antiretroviral therapy , immunology , psychiatry , cyp3a4 , cognition , cytochrome p450 , metabolism
Efavirenz (EFV) use is associated with neuropsychiatric side effects, which may include poor neurocognitive performance. We evaluated single nucleotide polymorphisms in genes that contribute to EFV pharmacokinetics and examined them in association with EFV concentrations in plasma and hair, as well as neurocognitive performance.