Open AccessFrequency of post treatment control varies by antiretroviral therapy restart and viral load criteria
Author(s) -
Jesse Fajnzylber,
Radwa Sharaf,
John N. Hutchinson,
Evgenia Aga,
Ronald J. Bosch,
Wendy Hartogensis,
Jeffrey M. Jacobson,
Elizabeth Connick,
Paul A. Volberding,
Daniel J. Skiest,
David M. Margolis,
Michael C. Sneller,
Susan J. Little,
Roy M. Gulick,
John W. Mellors,
Rajesh T. Gandhi,
Robert T. Schooley,
Keith Henry,
Pablo Tebas,
Steve Deeks,
TaeWook Chun,
Ann C. Collier,
Frederick Hecht,
Jonathan Z. Li,
Champ study team
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002978
Subject(s) - viral load , antiretroviral therapy , clinical trial , human immunodeficiency virus (hiv) , medicine , sensitivity (control systems) , virology , immunology , electronic engineering , engineering
Clinical trials including an analytical treatment interruption (ATI) are vital for evaluating the efficacy of novel strategies for HIV remissions. We briefly describe an interactive tool for predicting viral rebound timing in ATI trials and the impact of posttreatment controller (PTC) definitions on PTC frequency estimates. A 4-week viral load threshold of 1000 cps/ml provides both high specificity and sensitivity for PTC detection. PTC frequency varies greatly based on the definition of a PTC.