Open AccessAntiretroviral therapy administration reduces neuroinflammation without restoring brain-derived neurotrophic factor signaling in alcohol-administered simian immunodeficiency virus-infected macaques
Author(s) -
John K. Maxi,
Brittany Foret,
Angela M. Amedee,
Lee S. McDaniel,
Steve Nelson,
Liz Simon,
Scott Edwards,
Patricia E. Molina
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002896
Subject(s) - simian immunodeficiency virus , neuroinflammation , tropomyosin receptor kinase b , brain derived neurotrophic factor , neurotrophic factors , immunology , biology , viral load , medicine , receptor , virus , inflammation
The present study examined interactions between simian immunodeficiency virus (SIV), chronic binge alcohol (CBA), and antiretroviral therapy (ART) on growth factor signaling, neuroinflammatory markers, viral loads (VL), and CD4+ cell counts.