Open AccessComparison of predictors for terminal disease progression in simian immunodeficiency virus/simian-HIV-infected rhesus macaques
Author(s) -
Naofumi Takahashi,
Amir Ardeshir,
Gerard E. Holder,
Yanhui Cai,
Chie Sugimoto,
Kazuyasu Mori,
Mariluz Araínga,
Ziyuan He,
Yayoi Fukuyo,
Woong Ki Kim,
Elizabeth S. Didier,
Marcelo J. Kuroda
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002874
Subject(s) - simian immunodeficiency virus , viral load , monocyte , immunology , pathogenesis , virus , immunodeficiency , virology , t cell , biology , lentivirus , simian , immune system , viral disease
CD4+ T-cell decline and increasing virus levels are considered hallmarks of HIV/AIDS pathogenesis but we previously demonstrated in rhesus macaques that tissue macrophage destruction by simian immunodeficiency virus (SIV) infection associated with increased monocyte turnover also appear to impact pathogenesis. It remains unclear, however, which factors best predict onset of terminal disease progression and survival time. The objective of this study, therefore, was to directly compare these co-variates of infection for predicting survival times in retrospective studies of SIV/simian-HIV (SHIV)-infected adult rhesus macaques.