Open AccessNormal structural brain development in adolescents treated for perinatally acquired HIV: a longitudinal imaging study
Author(s) -
Malon Van den Hof,
Pien E J Jellema,
A. M. ter Haar,
Henriëtte J. Scherpbier,
Anouk Schrantee,
Antonia Kaiser,
Matthan W.A. Caan,
Charles B.L.M. Majoie,
Peter Reiss,
Ferdinand W.N.M. Wit,
HenkJan Mutsaerts,
Dasja Pajkrt
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002873
Subject(s) - white matter , grey matter , confidence interval , diffusion mri , hyperintensity , medicine , brain size , magnetic resonance imaging , psychology , nuclear medicine , radiology
Cross-sectional studies, including one from our NOVICE cohort [Neurological Visual and Cognitive performance in children with treated perinatally acquired HIV (PHIV) compared with matched HIV-negative controls], have revealed that the brains of children with PHIV have lower white matter and grey matter volumes, more white matter hyperintensities (WMH) and poorer white matter integrity. This longitudinal study investigates whether these differences change over time.