Open AccessLow CD4+ cell count nadir exacerbates the impacts of APOE ε4 on functional connectivity and memory in adults with HIV
Author(s) -
Fan Nils Yang,
Margarita Bronshteyn,
Sarah A. Flowers,
Matthew Dawson,
Princy Kumar,
G. William Rebeck,
R. Scott Turner,
David J. Moore,
Ronald J. Ellis,
Xiong Jiang
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002840
Subject(s) - memory impairment , hippocampus , disease , medicine , apolipoprotein e , episodic memory , alzheimer's disease , psychology , neuroscience , gerontology , cognition
Nearly half of individuals living with HIV in the USA are now 50 or older. This rapidly ageing populace may be at an increasingly greater risk of Alzheimer's disease. However, the potential interaction between HIV-disease and Alzheimer's disease pathogenesis (i.e. Alzheimer's disease genetic risk factors) on brain function remains an open question. The present study aimed to investigate the impact of APOE ε4 on brain function in middle-aged to older people with HIV (PWH), as well as the putative interaction between ε4 and HIV disease severity.