Open AccessThe association of human leukocyte antigen alleles with clinical disease progression in HIV-positive cohorts with varied treatment strategies
Author(s) -
Christina Ekenberg,
Joanne Reekie,
Adrian G. Zucco,
Daniel D. Murray,
Shweta Sharma,
Cameron Ross MacPherson,
Abdel Babiker,
Virginia L. Kan,
H. Clifford Lane,
James D. Neaton,
Jens Lundgren,
Smart Study Groups Insight Start
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002800
Subject(s) - immunology , human leukocyte antigen , viral load , hazard ratio , medicine , allele , proportional hazards model , disease , immune system , virus , oncology , antigen , biology , confidence interval , genetics , gene
The Strategic Timing of AntiRetroviral Treatment (START) and Strategies for Management of Antiretroviral Therapy (SMART) trials demonstrated that ART can partly reverse clinically defined immune dysfunction induced by HIV replication. As control of HIV replication is influenced by the HLA region, we explored whether HLA alleles independently influence the risk of clinical events in HIV+ individuals.