Open AccessStatin exposure and risk of cancer in people with and without HIV infection
Author(s) -
Roger Bedimo,
Lesley S. Park,
Fatima M Shebl,
Keith Sigel,
Christopher T Rentsch,
Kristina Crothers,
Maria C. RodriguezBarradas,
Matthew Bidwell Goetz,
Adeel A. Butt,
Sheldon T. Brown,
Cynthia Gibert,
Amy C. Justice,
Janet P. Tate
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002748
Subject(s) - medicine , hazard ratio , statin , proportional hazards model , cancer , cohort , cohort study , confidence interval , lower risk , oncology
To determine whether statin exposure is associated with decreased cancer and mortality risk among persons with HIV (PWH) and uninfected persons. Statins appear to have immunomodulatory and anti-inflammatory effects and may reduce cancer risk, particularly among PWH as they experience chronic inflammation and immune activation.