Open AccessGenome-wide association study of high-sensitivity C-reactive protein, D-dimer, and interleukin-6 levels in multiethnic HIV+ cohorts
Author(s) -
Brad T. Sherman,
Xiaojun Hu,
Kanal Singh,
Lillian Haine,
Adam Rupert,
James D. Neaton,
Jens Lundgren,
Tomozumi Imamichi,
Weizhong Chang,
H. Clifford Lane,
Smart Esprit,
Start Study Groups
Publication year - 2021
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002738
Subject(s) - biomarker , single nucleotide polymorphism , medicine , population , genome wide association study , genetic association , genotype , immunology , oncology , genetics , biology , gene , environmental health
Elevated levels of interleukin-6 (IL-6), D-dimer, and C-reactive protein (hsCRP) are associated with increased incidence of comorbid disease and mortality among people living with HIV (PLWH). Prior studies suggest a genetic basis for these biomarker elevations in the general population. The study objectives are to identify the genetic basis for these biomarkers among PLWH.