Open AccessAntiretroviral therapy reduces but does not normalize immune and vascular inflammatory markers in adults with chronic HIV infection in Kenya
Author(s) -
Tecla M Temu,
Jerry S Zifodya,
Stephen J. Polyak,
Jessica Wagoner,
Celestine N. Wanjalla,
Sarah Masyuko,
Jerusha Nyabiage,
John Kinuthia,
Gerald S. Bloomfield,
Stephanie T. Page,
Carey Farquhar
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002729
Subject(s) - medicine , cd14 , immunology , inflammation , dyslipidemia , viral load , cd163 , endothelial activation , monocyte , logistic regression , biomarker , immunosenescence , immune system , obesity , gastroenterology , macrophage , human immunodeficiency virus (hiv) , biology , in vitro , biochemistry
Markers of monocyte/macrophage activation and vascular inflammation are associated with HIV-related cardiovascular diseases (CVD) and mortality. We compared these markers among African people living with HIV (PLWH) and HIV-negative adults, and examined risk factors associated with elevated biomarkers (>75th percentile) in PLWH on antiretroviral therapy (ART).