Open AccessMaternal HIV status skews transcriptomic response in infant cord blood monocytes exposed to Bacillus Calmette--Guerín
Author(s) -
Chloe Jones,
Suzanne Rose,
Ashley Shutt,
Cristiana Cairo,
Natasha M. Bourgeois,
Manhattan Charurat,
Donald L. Sodora,
Matthew P. Wood
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002706
Subject(s) - chemokine , immunology , innate immune system , cd14 , ccl7 , biology , cytokine , immune system , cord blood , cxcl10 , monocyte , medicine
HIV-exposed uninfected (HEU) infants exhibit altered vaccine responses and an increased mortality compared with HIV-unexposed infants. Here, vaccine responses in HEU and HIV-unexposed cord blood monocytes (CBMs) were assessed following Bacillus Calmette--Guerín (BCG) treatment.