Open AccessLong noncoding RNA HOTAIRM1 promotes myeloid-derived suppressor cell expansion and suppressive functions through up-regulating HOXA1 expression during latent HIV infection
Author(s) -
Jinyu Zhang,
Bal Krishna Chand Thakuri,
Juan Zhao,
Lam Nguyen,
Lam Nguyen,
Dechao Cao,
Xindi Dang,
Sushant Khanal,
Madison Schank,
Zeyuan Lu,
Xiao Wu,
Zheng D. Morrison,
Mohamed El Gazzar,
Zhengke Li,
Yong Jiang,
Shunbin Ning,
Ling Wang,
Jonathan P. Moorman,
Zhi Q. Yao
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002700
Subject(s) - myeloid , biology , gene knockdown , myeloid derived suppressor cell , cd33 , cancer research , immunology , cell culture , microbiology and biotechnology , suppressor , stem cell , cd34 , genetics , cancer
Myeloid-derived suppressor cells (MDSCs) contribute to HIV progression by impairing antiviral immunity; however, the mechanisms responsible for MDSC development during HIV infection are incompletely understood. HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) is a long noncoding RNA (lncRNA) that plays a pivotal role in regulating myeloid cell development via targeting HOXA1. The role of HOTAIRM1--HOXA1 in the differentiation and functions of MDSCs during HIV infection remains unclear.