Open AccessNoninvasive detection of impaired pulmonary artery endothelial function in people living with HIV
Author(s) -
Erin Goerlich,
Monica Mukherjee,
Michael Schär,
Todd T. Brown,
Gabriele Bonanno,
Robert G. Weiss,
Allison G. Hays
Publication year - 2020
Publication title -
aids
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.195
H-Index - 216
eISSN - 1473-5571
pISSN - 0269-9370
DOI - 10.1097/qad.0000000000002671
Subject(s) - medicine , pulmonary artery , nitric oxide , pulmonary hypertension , cardiology , vasodilation , endothelial dysfunction , exhaled nitric oxide , pulmonary function testing , lung , lung function
People living with HIV (PLWH) have an increased risk of pulmonary vascular disease and pulmonary hypertension. Endothelial cell dysfunction is thought to contribute, but human studies have been limited by the invasive nature of conventional measures of pulmonary artery endothelial function (PAEF). We report here a noninvasive MRI approach to measure nitric oxide mediated PAEF by quantifying changes in pulmonary artery area and blood flow during isometric handgrip exercise (IHE), an endothelial nitric oxide dependent stressor. We used this to test the hypothesis that PLWH have impaired PAEF, even before development of pulmonary hypertension.